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The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility.There is a 10-fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. .

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No adverse effect levels in the rat and dog were 60 mg/kg and 15 mg/kg respectively.- diabetes mellitus sildenafil 100mg.

In 2010, a pilot study of Vardi studiÃ2 a stoneâuse of the LISWTactivities in physics, with significant improvements âthe index of the control. The beneficial effects of lifestyle changes success story.